Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents
O Picazo, E Estrada-Camarena… - European journal of …, 2006 - Elsevier
This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety
of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-
HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Rats
ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour
paradigm and in an automatic activity counter. The highest values of time spent burying
were observed in the 12-week group. In general, the 12-week group was more responsive to …
of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-
HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Rats
ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour
paradigm and in an automatic activity counter. The highest values of time spent burying
were observed in the 12-week group. In general, the 12-week group was more responsive to …
